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Robert E Swillo Selected Research

1- (2- aminoacetyl)- 4- benzamidopyrrolidine- 2- carboxylic acid

9/2009GAP-134 ([2S,4R]-1-[2-aminoacetyl]4-benzamidopyrrolidine-2-carboxylic acid) prevents spontaneous ventricular arrhythmias and reduces infarct size during myocardial ischemia/reperfusion injury in open-chest dogs.
8/2009Discovery of a class of potent gap-junction modifiers as novel antiarrhythmic agents.
6/2009The gap junction modifier, GAP-134 [(2S,4R)-1-(2-aminoacetyl)-4-benzamido-pyrrolidine-2-carboxylic acid], improves conduction and reduces atrial fibrillation/flutter in the canine sterile pericarditis model.

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Robert E Swillo Research Topics

Disease

3Myocardial Ischemia (Ischemic Heart Diseases)
09/2009 - 01/2002
3Atrial Fibrillation
08/2009 - 02/2009
2Reperfusion Injury
09/2009 - 04/2006
2Infarction (Infarctions)
09/2009 - 04/2006
2Ventricular Tachycardia
09/2009 - 08/2009
2Hemorrhage
03/2006 - 08/2005
2Thrombosis (Thrombus)
03/2006 - 08/2005
1Ventricular Premature Complexes (Premature Ventricular Contraction)
09/2009
1Ischemia
09/2009
1Cardiac Arrhythmias (Arrythmia)
08/2009
1Pericarditis
06/2009
1Coronary Occlusion
08/2005
1Vascular Remodeling
11/2003

Drug/Important Bio-Agent (IBA)

31- (2- aminoacetyl)- 4- benzamidopyrrolidine- 2- carboxylic acidIBA
09/2009 - 06/2009
2Carboxylic AcidsIBA
09/2009 - 06/2009
2pyrrolidineIBA
09/2009 - 06/2009
2Plasminogen Activators (Plasminogen Activator)IBA
08/2005 - 11/2003
1Polyvinyl Chloride (PVC)IBA
09/2009
1DipeptidesIBA
09/2009
1hydroxide ionIBA
08/2009
1AcidsIBA
02/2009
1rotigaptideIBA
04/2006
1Glycoproteins (Glycoprotein)IBA
03/2006
1von Willebrand FactorIBA
03/2006
1Clopidogrel (Plavix)FDA Link
03/2006
1Adenosine Diphosphate (ADP)IBA
08/2005
1Pharmaceutical PreparationsIBA
08/2005
1Plasminogen Activator Inhibitor 1IBA
08/2005
1Acetic Acid (Vinegar)FDA LinkGeneric
08/2005
1CollagenIBA
08/2005
1tiplaxtininIBA
08/2005
1Tissue Plasminogen Activator (Alteplase)FDA Link
11/2003
1SphingosineIBA
01/2002

Therapy/Procedure

1Oral Administration
08/2009